Before taking any drug, be it supplement or treatment, it’s wise to get full, science-backed data about it. You should know what results and benefits to expect, and more importantly, be aware of the possible side effects. This is vital for feeling comfortable with your decision.
The world of bodybuilding supplements, including peptide ones, is no different. In fact, peptide supplements are extremely popular nowadays since they promise to improve almost everything in the human organism – weight loss, metabolism, skin condition, wound healing, injury recovery, and more. The formula, known as BPC-157, is today’s king. You’ve probably already heard or read about the BPC-157 peptide’s positive impact. But what about its side effects?
Here, we’ll discuss this compound in detail, evaluate its advantages and potential dangers. Our BPC-157 review is based on numerous studies and patients’ reports so that you’ll be able to make a thoughtful choice and determine whether BPC-157 peptide is right for you.
- 1 What are Peptides?
- 2 What is BPC-157?
- 3 BPC-157 Benefits: Scientific Evidence
- 4 BPC-157 Side Effects
- 5 How To Use BPC-157?
- 6 FAQs
- 7 Conclusion
What are Peptides?
Peptides are biological molecules found naturally in all living organisms. They are actually short strings of amino acids, normally including 2-50 amino acids. Peptides play a vital role in all manner of biological activity.
Treatment with peptides uses those already present chains to regulate and renew functions. They link to and “tell” other cells what to do, mimicking or replacing functions of natural peptides. Peptides are capable of rewriting body chemistry to enhance restoration, anabolism, and homeostasis.
What is BPC-157?
BPC stands for “Body protection compound”, it’s also known as PL 14736. This compound is a chain of amino acids that form a peptide. The formula contains 98 atoms of hydrogen, 62 atoms of carbon, 22 atoms of oxygen, and 16 atoms of nitrogen. Actually, BPC is a protective peptide from our gut. However, it can’t be found in nature by itself, that’s why most scientists classify BPC-157 as a synthetic peptide.
BPC-157 got its name due to the ability to quickly heal various injuries, reduce fatigue, and retain an anabolic state post-workout; these are incredible features, useful for time-intensive exercise.
Researchers conducted a multitude of studies on lab rats to explore BPC peptide effectiveness. BPC-157 revealed a host of benefits, however, negative effects were found as well. We’ll discuss both pros & cons in detail further in the article.
What are the Reasons for Taking BPC-157?
There are several reasons why to take BPC-157: gut and joint health, trauma, and tissue healing. Although there are plenty of other reasons to consider taking this compound, you should know that those benefits have less scientific evidence. BPC-157 human trials have not been finished, and all studies done on this compound are animal studies.
And speaking about the healing properties of BPC-157: animal studies have shown that this compound promotes tissue and injury healing, wound repair, and cellular regrowth. These benefits are achieved through different mechanisms, including:
- Being attracted to particular chemical signals released by damaged tissues;
- Enhancing growth hormone receptors in injured tissues;
- Boosting angiogenesis;
- Increasing blood vessels;
- Improving collagen production.
Similarly, by healing and repairing soft tissue structures like muscles, tendons, ligaments, which may be degraded because of aging processes, overuse, or strain, BPC peptide can stabilize joints, thus supporting joint strength. Soft tissue healing can be impaired through corticosteroids, whether they are native to the body or given as medical treatment. Animal tests revealed that BPC-157 can nullify this deterioration, allowing to improve these crucial structures that bind muscles to the skeleton.
And last but not least, BPC-157 treats almost all types of digestive diseases in animals. It’s capable of reducing the harm induced by the overuse of NSAIDs (painkillers). NSAIDs are responsible for ulcers or stomach damage and intestines. Bepecin (BPC-157) can help remedy that injury and enhance overall gut health.
How Does It Work?
BPC-157 acts during the proliferation and recovery phase of wound healing. It enhances cell migration and cell survival rates under oxidative stress. Let’s discuss 3 phases of wound healing and see the way BPC-157 can help.
Phase 1. Inflammatory phase – this phase is the body’s initial reaction to stabilize a wound; blood vessels constrict and create a clot to stop bleeding. Once the blood flow stops, the blood vessels begin to dilate to allow vital cells to return to the injured area to promote wound healing and prevent infection. During this phase, an individual experiences pain, redness, swelling, and heat; it’ll last about 1-5 days.
Phase 2. Proliferation and recovery phase – during this phase, the wound is being repaired through cell migration. Cell migration is a process that brings healthy cells to the wound. It has to receive enough nutrients and oxygen to produce healthy connective tissue and new blood vessels. This process is called “angiogenesis”. If you take BPC-157, the connective tissue will grow faster since this compound enhances cell migration and it helps increase cell survival rate under oxidative stress. In other words, BPC-157 speeds up the process of angiogenesis.
Phase 3. Remodeling phase – the final phase is a maturation of the wound, and it occurs when the wound has closed; however, the tissue can’t return to its normal condition for up to 2 years. BPC-157 is considered to be an effective method to heal the body quicker than it would recover on its own.
BPC-157 Benefits: Scientific Evidence
Studies on BPC-157 began in 1991. Due to numerous health benefits, scientists want to take this compound to the future, that’s why they keep researching it. The studies have been performed in-vivo and in-vitro.
We’ve consolidated all health benefits you can expect from BPC-157, they all are scientifically proven.
Inflammatory Bowel Disease
There are plenty of references to online and published scientific studies that suggest BPC-157 as a safe and effective solution for treating inflammatory bowel disease (IBD). However, the results haven’t been peer-reviewed.
In any case, animal tests showed that BPC-157 reduced inflammation in rats with IBS.
Muscle and Tendon Healing
BPC-157 showed amazing results in improving muscle healing in rats whose muscles were crushed or cut. This effect held true even when rats were given corticosteroids like hydrocortisone, known for slowing down the healing process.
Therefore, BPC-157 is a great peptide for muscle growth since it helps to recover muscles after intense workouts.
Healing Burns, Cuts, and Broken Bones
Furthermore, BPC-157 injection enhanced the recovery of broken bones in rabbits.
Protecting the Brain and Nervous System
Mice trials showed that BPC-157 injections helped reduce brain damage in rodents suffering from traumatic brain injury. If mice were given the compound before the brain injury, they tend to stay conscious and less likely to die.
BPC 157 peptide is also beneficial for the nervous system. Rats with nerve damage in the legs showed nerve cell regrow and healing after getting the BPC-157 injection. Moreover, this compound protected rodents from drug-induced seizures.
BPC-157 can even positively impact the mood. It reduced depression-like symptoms in rats. Scientists compared this effect to that of conventional antidepressants.
Ulcers and Gut Health
Numerous scientific data prove that BPC-157 is extremely beneficial for gut healing. In rats, it effectively treated stomach ulcers, gastrointestinal fistulas (abnormal openings in the digestive tract that cause fluids to leak), and protected intestines from toxic damage. Next, BPC-157 decreased inflammation in rodents with arthritis and stomach ulcers. The peptide also reduced inflammation in rats with the sore esophagus. More than that, BPC-157 may help to soothe the stress response from the inside out since it acts on the gut-brain axis.
Damage Caused By NSAIDs
Non-steroidal anti-inflammatory drugs (NSAIDs) include painkillers like aspirin or ibuprofen. Normally, they are safe if used correctly, but if these drugs are taken in high doses, they cause damage to the stomach and liver. Animal tests showed that BPC-157significantly reduced the toxic impact caused by NSAIDs.
BPC-157 may be useful in countering drug intoxication. Although the combination of peptides and morphine made rats more sensitive to pain than those given just morphine, they were still less sensitive than rodents that received nothing. Moreover, BPC-157 reduced abnormal behavior in rats when given amphetamines. It counteracts the chemical imbalances amphetamines trigger, especially on the dopamine system.
BPC-157 is considered to be a mild painkiller. Rodents injected with this compound felt less pain to such unpleasant stimuli as pinching. Notably, they received only BPC-157, no painkillers.
Balancing Blood Pressure
In rats, BPC-157 stabilized blood pressure. In the first group of rats, high blood pressure was chemically induced, peptide injection lowered it. In the second group, rats were given L-arginine, which decreases blood pressure, BPC-157 increased it.
Balancing Potassium Levels
The condition when blood potassium levels become too high is called hyperkalemia. Hyperkalemia is usually a result of kidney disease, it can lead to fatigue, muscle weakness, irregular heart rhythms, and even death. The study revealed that rats with hyperkalemia who received BPC-157 survived and showed fewer symptoms.
BPC-157 Side Effects
We’ve mentioned lots of studies above, and they all revealed so many positive effects of BPC-157 that you might want to buy it right away. Unfortunately, it’s not all rosy! Those studies involved rodents while human studies and experience with this compound are limited.
In one research, 32 healthy volunteers were administered BPC-157 enemas, they reported to have no adverse effects. However, enemas are not the normal route of administration, plus, this trial didn’t reveal any important details like dosage. The results haven’t been peer-reviewed or presented at any conferences. Since there aren’t solid scientific trials in humans, we can only assume what BPC-157 side effects to expect. The most common of them can relate to GI gastrointestinal system, and include:
- Alterations to bowel habits;
- Gas and bloating;
Other side effects that may happen:
- Alterations in hunger patterns or weight (for this reason, you’d better look for other peptides for weight loss);
- Hot or cold flashes.
The good news is that animal studies haven’t reported any obvious adverse reactions. Nevertheless, it doesn’t exclude the possibility of various effects on people.
Fortunately, some of the world’s top scientists are currently studying BPC-157, and try to determine whether this compound can become a life-changer for us.
But is BPC-157 legal nowadays? There is no legal basis for this compound as a dietary supplement, food, or drug, it also can’t be used in compounded mediations. BPC-157 is not approved by the Food and Drug Administration (FDA). However, there is evidence that it’s illegally included in some anti-aging & wellness products and treatments.
Rare And Theoretical Side Effects
There are several rare or purely theoretical side effects of BPC-157 that have not been found in individual reports or studies to date.
However, it’s a possible way of action in which the drug works, and hence worth noting – even if they never develop in larger or longer-term research.
In any case, with any medication, you should always consult with a doctor for the dosing guidelines. It’s advisable to use the lowest efficient dose needed to achieve the desired result. Higher doses increase the risk of side effects without increasing positive results.
The most serious potential BPC-157 side effects might include:
- Cancer (tumor growth) – as we mentioned above, BPC-157 boosts angiogenesis – production of new blood vessels, it can be involved in the growth of tumors, benign or malignant, through this process.
- Change to blood pressure – typically, BPC-157 has a stabilizing effect – it increases low blood pressure or decrease high blood pressure. But considering the fact that it really has the effect, it’s possible for negative shifts. Besides, BPC-157 can interfere with the effects of other medications.
- Problems with kidneys or liver – some peptides are associated with liver or kidney toxicity. Although BPC-157 is not shown to have this issue, individuals with existing liver or kidney diseases should take extra precautions and try to avoid peptide supplements. Side effects of BPC-157 in this sphere aren’t well-known.
- Abnormal heart rhythms – studies showed that BPC-157 has a positive impact on moderating heart rhythms. Since it has such an ability, it potentially can cause unwanted rhythm issues. It’s advisable for people suffering from heart diseases to stay steer clear from BPC-157, or at least take extra care before taking this compound.
- Harm or toxicity to the fetus – peptides, including BPC-157, haven’t been studied in pregnant women, so the effects on the fetus are unclear. We also don’t know whether peptides are passed through breastmilk. However side effects can still emerge, and be potentially harmful or toxic. So women that are planning pregnancy, are expecting, or already nursing should avoid BPC-157 supplementing or treating.
Although mentioned above side effects are rare or theoretical, the potential for them does exist, like with any other medication. So, if you have any concerns or doubts, discuss them with your doctor, healthcare provider, or prescriber before taking any supplements, including BPC-157.
How To Use BPC-157?
BPC-157 performs systemically, and there are 3 options to take it. You can inject it subcutaneously – under-the-skin method, intramuscularly – stab the needle into the muscle. Both methods require inserting the needle as close to the area of pain as possible. Or you can just take the solution orally.
- Oral administration
There are 3 main variants of oral administration: BPC-157 capsules, BPC-157 tablets, or BPC-157 spray. Using these options are quite straightforward – you just need to take capsules or tablets with or without food. If you choose a spray solution, just spray it slowly into your mouth, hold it for up to 120 seconds, then swallow.
- Subcutaneous injections
Subcutaneous injection is a relatively simple procedure. You just need to be ok with needles. Pinch the skin near the injury and stick the needle into the pinched skin. Or, even better, you can ask for help.
- Intramuscular injections
Intramuscular injections may seem (and it actually is) a tough procedure unless you’re an experienced nurse. You have to stab the whole needle through the skin and into the muscle as close to the injured area as possible. However, it’s advisable to ask a professional to do it for you.
Before you even think whether you should take BPC-157 or decide on BPC-157 dosage, you must understand that there weren’t any trusted scientific studies in humans. Therefore, there isn’t any proven dose. Furthermore, the Food and Drug Administration (FDA) didn’t approve this drug for any health conditions. Supplement manufacturers and users established unofficial BPC-157 dosage based on trial and error.
In mice and rats who were given drugs in the drinking water, the dosing ranged from 10 nanograms to 10 mcg (micrograms) per kilogram. As for adult human, here is an approximate BPC-157 dosing:
- 110 mg for a 150 lbs individual;
- 145 mg for 200 lbs individuals;
- 180 mg for a 250 lbs individuals.
But, please, remember that unless clinical trials in humans are carried out, we can’t consider any dose of BPC-157 safe and effective. Besides, lots of animal tests were performed using injections into the stomach instead of into the muscle or under the skin.
Limitations And Caveats
All trials mentioned above were done in rodents or cells in dishes. Obviously, these studies are valuable, but let’s remember that mice and rats are not humans. Therefore, it’s crucial to understand that treatment may not feature the same effect in both species. Moreover, the same several labs with the same scientists listed as co-authors performed most of the studies. Unfortunately, it increases the likelihood of bias, especially if researchers hold a patent on the compounds that are studied.
How Long Can BPC-157 Be Used?
According to research, BPC-157 can be taken for up to a month, until symptoms improve. If the trauma requires extra doses after the first month of use, stop taking the compound for 2 weeks, then continue with it. Make sure to have a 2-week break after every month of use.
How Long Does BPC-157 Take to Work?
BPC-157 works ultimately fast. Although the result will depend on the severity of the injury, you may notice a considerable improvement within 24-48 hours.
How Long Do The Effects Of This Medication Typically Last?
Since there were not any human trials of BPC-157, researchers can’t answer this question yet.
What Are Storage Requirements For BPC-157?
BPC peptide is easy to store compared to other solutions, e.g., TB-500 vs BPC-157. It’s recommended to store BPC-157 blend for injections in the fridge, it’ll extend the compound’s shelf-life. Oral solutions do not need refrigeration, just put them in a cool, dry place.
Researchers have done dozens of mice and rats trials on BPC-157; that revealed amazing results. The positive effects of this compound extend beyond the stomach and intestinal tract. In fact, it’s capable of healing wounds, inflammations, and improving the condition of injured muscles, joints, and bones. It is also assumed to have a positive effect on the brain and the central nervous system.
Although BPC-157 shows promise, the majority of studies were performed on rodents, therefore trials in humans are needed to demonstrate and prove its effectiveness, and more importantly, reliability. Fortunately, research continues, and we hope that BPC-157 will soon become a game-changer for all of us. However, if you decide to take this peptide in the nearest future, make sure to consult with your doctor!
What do you think of BPC-157? Have you ever tried peptides? If yes, share your experience with us! As for us, we can’t wait for this compound to get official approval! Let us know what you think in the comment section below!